Ameliorating Effect of Ashwagandha (Withania Somnifera) Extract on Hippocampus and Growth Plate Changes Associated With Propylthiouracil Induced Hypothyroidism in Juvenile Rats
نویسندگان
چکیده
Background: Hypothyroidism is a decrease in the production of thyroid hormones and leads to gland dysfunction. Ashwagandha extract was used as an ayurvedic treatment supposed be antihypothyroidism agent. Objectives: investigate impact ashwagandha (Ash) on propylthiouracil (PTU)-induced hypothyroidism rats. Subjects Methods: The rats were divided into three groups, control group, PTU (hypothyroid) group (6mg/kg/day by oral route), route) +Ash (50mg/kg/day treated group. All continued for 30 days. At end experiment, measurement serum T3, T4 TSH performed. Thyroid gland, right sided tibia dentate gyrus region hippocampus examined using histological, histochemical immunohistochemical studies. measurements statistically analyzed. Results: Decrease T3 congestion blood capillaries, follicular distortion, vacuolar degeneration some cells exhibited hypothyroid Histological changes growth plate cartilage form matrix deposition thickness detected. Dentate showed distorted granule cell layer. Immunohistochemically, low expression GFAP expressed astrocytes. PTU+Ash improvement previous changes. Conclusion: Administration with displayed protective effect its associated histological gyrus. Higher doses should extrapolation if it may give better results than dose.
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ژورنال
عنوان ژورنال: ???? ???? ?? ??????
سال: 2023
ISSN: ['2521-4365', '1810-9543']
DOI: https://doi.org/10.47723/kcmj.v19i1.920